The zebrafish embryo model is an effective and accurate tool for rapidly assess nanomaterial toxicity at low cost. This model is also well-suited to identify areas of relative distribution of nanomaterials that are fluorescently labeled. ZF BioLabs offers a nanomaterial toxicity bioassay including LC50 and EC50 of several morphological and functional endpoints. Information gained from this dynamic in vitro/ in vivo assay can be applied to predict effects in other systems since genetic, cellular and physiological processes are highly conserved between zebrafish and humans, especially early in development.
With the information gained using this technology is useful as feedback for scientists & engineers designing novel nanomaterials, considering potential toxicity and ensuring their development having the least amount of toxic potential. ZF BioLabs presented a poster at the 4th NanoSpain Workshop. Download the poster.
There are already available ZF ACUTOX Kit & ZF ACUTOX- PLUS Kit