Casting a wide net: use of diverse model organisms to advance toxicology.

Casting a wide net: use of diverse model organisms to advance toxicology.

Toxicology – the research of how chemical compounds work together with organic techniques – has clear relevance to human well being and illness. Persistent publicity to pure and artificial chemical compounds is an unavoidable a part of residing on our planet; but, we perceive little or no concerning the results of publicity to the overwhelming majority of chemical compounds. Whereas epidemiological research can present robust statistical inference linking chemical publicity to illness, analysis in mannequin techniques is crucial to elucidate the mechanisms of motion and to foretell outcomes.

Most analysis in toxicology makes use of a handful of mammalian fashions that symbolize a number of distinct branches of the evolutionary tree. This slender focus constrains the understanding of chemical-induced illness processes and techniques which have developed in response to exposures. We advocate for casting a wider internet in environmental toxicology analysis to make the most of various mannequin techniques, together with zebrafish, and carry out extra mechanistic research of mobile responses to chemical exposures to shift the notion of toxicology as an utilized science to that of a primary science. This more-inclusive perspective will enrich the sector and may stay central to analysis on chemical-induced illness.

Traditionally, analysis in toxicology has utilized non-human mammalian species, notably rats and mice, to check in vivo the results of poisonous publicity on physiology and conduct. Nevertheless, moral issues and the overwhelming enhance within the variety of chemical compounds to be screened has led to a shift away from in vivo work. The decline in in vivo experimentation has been accompanied by a rise in various strategies for detecting and predicting detrimental results: in vitro experimentation and in silico modeling.

But, these new methodologies can’t substitute the necessity for in vivo work on animal physiology and conduct. The event of recent, non-mammalian mannequin techniques exhibits nice promise in restoring our skill to make use of behavioral endpoints in toxicological testing. Of those techniques, the zebrafishDanio rerio, is the mannequin organism for which we’re accumulating sufficient information in vivoin vitro, and in silico to allow us to develop a complete, highthroughput toxicology screening system.

Developmental toxicity of fipronil in early improvement of zebrafish (Danio rerio) larvae: Disrupted vascular formation with angiogenic failure and inhibited neurogenesis.

Fipronil has been extensively utilized in agriculture to forestall aggressive bugs from damaging agricultural merchandise. Fipronil residues flow into within the setting they usually have been detected in non-targeted organisms in aquatic environments. To check the impact of fipronil toxicity on environmental well being, 6 h put up fertilization (hpf) zebrafish embryos have been handled with fipronil for 72 h. LC50 worth was obtained by making use of various concentrations of fipronil to zebrafish embryos for 72 h.

As zebrafish embryos are helpful vertebrate fashions for finding out developmental and genetic findings in toxicology analysis, they have been uncovered to fipronil to check detailed elucidating mechanisms with hazardous finish factors of toxicity. Cell cycle arrest-related apoptosis supported pathological alterations, equivalent to elevated mortality, shortened physique size, and lowered hatchability.

Moreover, noticed coronary heart defects, together with edema and irregular heartbeat have been triggered because of irregular blood circulation. In transgenic zebrafish fashions (fli1:eGFP and olig2:dsRED), disrupted blood vessel formations have been indicated by eGFP+ endothelial cells. Furthermore, neurogenic defects have been noticed by finding out dsRED+ motor neurons and oligodendrocytes. This research demonstrates fipronil accumulation in aquatic setting and its skill to impair important processes, equivalent to angiogenesis and neurogenesis throughout early developmental stage of zebrafish, together with normal developmental toxicity.

Casting a wide net: use of diverse model organisms to advance toxicology.

Twenty years of transcriptomics, 17alpha-ethinylestradiol, and fish.

In aquatic toxicology, maybe no pharmaceutical has been investigated extra intensely than 17alpha-ethinylestradiol (EE2), the lively ingredient of the contraception capsule. On the flip of the century, the fields of comparative endocrinology and endocrine disruption analysis witnessed the emergence of omics applied sciences, which have been quickly tailored to characterize potential hazards related to exposures to environmental estrogens, equivalent to EE2.
Since then, vital advances have been made by the scientific neighborhood, and in consequence, a lot has been realized about estrogen receptor signaling in fish from environmental xenoestrogens. Vitellogenin, the egg yolk precursor protein, was recognized as a significant estrogen-responsive gene, establishing itself because the premier biomarker for estrogenic exposures. Omics research have recognized a plethora of estrogen responsive genes, contributing to a wealth of data on estrogen-mediated regulatory networks in teleosts.
There have been ∼40 research that report on transcriptome responses to EE2 in quite a lot of fish species (e.g., zebrafish, fathead minnows, rainbow trout, pipefish, mummichog, stickleback, cod, and others). Information on the liver and testis transcriptome dominate within the literature and have been the topic of many EE2 research, but there stay information gaps for different tissues, such because the spleen, kidney, and pituitary. Inter-laboratory genomics research have revealed transcriptional networks altered by EE2 remedy within the liver; networks associated to amino acid activation and protein folding are elevated by EE2 whereas these associated to xenobiotic metabolism, immune system, circulation, and triglyceride storage are suppressed.

Zebrafish Growth Hormone Mutant Protein

20-abx260619
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  • 1 mg
  • 50 ug
  • 5 ug

Zebrafish Somatotropin, G113R mutant (GH1) Protein

abx260619-10g 10 µg
EUR 325

Zebrafish Somatotropin, G113R mutant (GH1) Protein

abx260619-2g 2 µg
EUR 225

Zebrafish Growth Hormone mutant (G119R) Recombinant Protein

500-023 50 µg
EUR 278.25
Description: Recombinant zebrafish growth hormone mutant G119R (zbGH mutant) produced in E.Coli (22 K) is a single, non-glycosylated, polypeptide chain containing 185 amino acids with an additional Ala at its N-terminus and having a molecular mass of 21187 Dalton.

Zebrafish Growth Hormone mutant (G119R) Recombinant Protein

500-023S 10 µg
EUR 178.5
Description: Recombinant zebrafish growth hormone mutant G119R (zbGH mutant) produced in E.Coli (22 K) is a single, non-glycosylated, polypeptide chain containing 185 amino acids with an additional Ala at its N-terminus and having a molecular mass of 21187 Dalton.

Recombinant Zebrafish Growth Hormone Mutant

7-00574 5µg Ask for price

Recombinant Zebrafish Growth Hormone Mutant

7-00575 50µg Ask for price

Recombinant Zebrafish Growth Hormone Mutant

7-00576 1mg Ask for price

Recombinant Zebrafish Growth Hormone Mutant

cyt-709-10g 10µg
EUR 60

Recombinant Zebrafish Growth Hormone Mutant

cyt-709-1mg 1mg
EUR 2300

Recombinant Zebrafish Growth Hormone Mutant

cyt-709-50g 50µg
EUR 145

OPPA02407-5UG - GH Zebrafish Protein

OPPA02407-5UG 5ug
EUR 70

Recombinant Zebrafish GH Protein, Untagged, E.coli-1mg

QP10635-1mg 1mg
EUR 2829.6

Recombinant Zebrafish GH Protein, Untagged, E.coli-10ug

QP10635-10ug 10ug
EUR 186

Recombinant Zebrafish GH Protein, Untagged, E.coli-50ug

QP10635-50ug 50ug
EUR 241.2

Zebrafish GH(Growth Hormone) ELISA Kit

ELK9404-48T 48T Ask for price
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Zebrafish GH protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Zebrafish GH. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Zebrafish GH in the samples is then determined by comparing the OD of the samples to the standard curve.

Zebrafish GH(Growth Hormone) ELISA Kit

ELK9404-96T 96T Ask for price
Description: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Zebrafish GH protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Zebrafish GH. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Zebrafish GH in the samples is then determined by comparing the OD of the samples to the standard curve.

Zebrafish Talin (TLN) Protein

20-abx655190
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  • 100 ug
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  • 1 mg
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Zebrafish Talin (TLN) Protein

abx655190-10g 10 µg
EUR 2112.5

Zebrafish Talin (TLN) Protein

abx655190-50g 50 µg
EUR 5300

Zebrafish Growth Hormone Protein

20-abx260620
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  • 1 mg
  • 50 ug
  • 5 ug

Zebrafish Somatotropin (GH1) Protein

abx260620-10g 10 µg
EUR 325

Zebrafish Somatotropin (GH1) Protein

abx260620-2g 2 µg
EUR 225

Danio rerio (zebrafish) VEGFA Protein

E40PZE003 20ug
EUR 495

Zebrafish Cathepsin L (CTSL) Protein

20-abx652813
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Zebrafish Cathepsin L1 (CTSL) Protein

abx652813-5mg 5 mg
EUR 5300

Zebrafish Interleukin 15 (IL15) Protein

20-abx653977
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  • 100 ug
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  • 1 mg
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Zebrafish Interleukin 15 (IL15) Protein

abx653977-100g 100 µg
EUR 8012.5

Zebrafish Interleukin 15 (IL15) Protein

abx653977-200g 200 µg Ask for price

Zebrafish Interleukin 15 (IL15) Protein

abx653977-50g 50 µg
EUR 3200

Zebrafish Interleukin 12B (IL12B) Protein

20-abx653962
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  • 100 ug
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  • 1 mg
  • 200 ug
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Zebrafish Interleukin 12B (IL12B) Protein

abx653962-5mg 5 mg
EUR 2112.5

Zebrafish Galactosidase Beta (GLb) Protein

20-abx653494
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  • 100 ug
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Zebrafish Beta-Galactosidase (GLB1) Protein

abx653494-100g 100 µg
EUR 5300

Zebrafish Beta-Galactosidase (GLB1) Protein

abx653494-200g 200 µg Ask for price

Zebrafish Beta-Galactosidase (GLB1) Protein

abx653494-50g 50 µg
EUR 2112.5

Recombinant Zebrafish A1AT Protein (aa 1-124)

VAng-2983Lsx-1mg 1 mg
EUR 3820.8
Description: Recombinant Zebrafish Alpha 1 Antitrypsin Antigen is expressed in E. coli. (Uniprot ID: Q1L8X2)

Recombinant Zebrafish A1AT Protein (aa 1-124)

VAng-2983Lsx-200g 200 µg
EUR 2337.6
Description: Recombinant Zebrafish Alpha 1 Antitrypsin Antigen is expressed in E. coli. (Uniprot ID: Q1L8X2)

Recombinant Zebrafish A1AT Protein (aa 1-124)

VAng-2983Lsx-500g 500 µg
EUR 2568
Description: Recombinant Zebrafish Alpha 1 Antitrypsin Antigen is expressed in E. coli. (Uniprot ID: Q1L8X2)

Zebrafish Growth Hormone Recombinant Protein

500-022 50 µg
EUR 278.25
Description: Recombinant zebrafish growth hormone (zbGH) produced in E.Coli (22 K) is a single, non-glycosylated, polypeptide chain containing 185 amino acids with an additional Ala at its N-terminus and having a molecular mass of 21187 Dalton.

Zebrafish Growth Hormone Recombinant Protein

500-022S 10 µg
EUR 178.5
Description: Recombinant zebrafish growth hormone (zbGH) produced in E.Coli (22 K) is a single, non-glycosylated, polypeptide chain containing 185 amino acids with an additional Ala at its N-terminus and having a molecular mass of 21187 Dalton.

Recombinant Zebrafish Cxadr Protein (aa 23-241)

VAng-Cr4512-1mgEcoli 1 mg (E. coli)
EUR 4876.8
Description: Zebrafish Coxsackievirus and adenovirus receptor homolog (cxadr), recombinant protein.

Recombinant Zebrafish Cxadr Protein (aa 23-241)

VAng-Cr4512-500gEcoli 500 µg (E. coli)
EUR 3261.6
Description: Zebrafish Coxsackievirus and adenovirus receptor homolog (cxadr), recombinant protein.

Recombinant Zebrafish ALCAM Protein (aa 25-507)

VAng-2956Lsx-1mg 1 mg
EUR 6906
Description: Recombinant Zebrafish ALCAM is expressed in E. coli. (Uniprot ID: Q90460)

Recombinant Zebrafish ALCAM Protein (aa 25-507)

VAng-2956Lsx-500g 500 µg
EUR 4233.6
Description: Recombinant Zebrafish ALCAM is expressed in E. coli. (Uniprot ID: Q90460)

Zebrafish Creatine Kinase, Muscle (CKM) Protein

20-abx653069
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  • 100 ug
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Zebrafish Creatine Kinase, Muscle (CKM) Protein

abx653069-100g 100 µg
EUR 5300

Zebrafish Creatine Kinase, Muscle (CKM) Protein

abx653069-200g 200 µg Ask for price

Zebrafish Creatine Kinase, Muscle (CKM) Protein

abx653069-50g 50 µg
EUR 2112.5

Zebrafish Bone Morphogenetic Protein 4 (BMP4) Protein

20-abx652682
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  • 100 ug
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  • 1 mg
  • 200 ug
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Zebrafish Bone Morphogenetic Protein 4 (BMP4) Protein

abx652682-5mg 5 mg
EUR 537.5

Recombinant Zebrafish VEGF165 Protein (aa 1-188)

VAng-Cr4056-100g 100 µg
EUR 2841.6
Description: Recombinant Zebrafish VEGF165 Protein (Met1-Arg188) was expressed in Baculovirus-Insect Cells, with a molecular weight of 19.2 kDa. (Accession ID: O73682)

Recombinant Zebrafish VEGF165 Protein (aa 1-188)

VAng-Cr4056-5g 5 µg
EUR 456
Description: Recombinant Zebrafish VEGF165 Protein (Met1-Arg188) was expressed in Baculovirus-Insect Cells, with a molecular weight of 19.2 kDa. (Accession ID: O73682)

Danio rerio (zebrafish) efnb2a Protein, His Tag

E40PZE001 20ug
EUR 495

Danio rerio (zebrafish) BMP-2 Protein, Fc Tag

E40PZE002 20ug
EUR 495

Zebrafish Id1 Rbt pAb, Protein A purified, 25UG

A014-25UG 25UG
EUR 510

Zebrafish Anti-Mullerian Hormone (AMH) Protein (BSA)

20-abx651052
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  • 100 ug
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  • 1 mg
  • 200 ug
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Zebrafish Anti-Mullerian Hormone (AMH) Protein (OVA)

20-abx651053
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Zebrafish Fibroblast Growth Factor 6 (FGF6) Protein

20-abx653400
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Zebrafish Fibroblast Growth Factor 6 (FGF6) Protein

abx653400-5mg 5 mg
EUR 5300

OPCA02179-1MG - D2HGDH Recombinant Protein (Zebrafish)

OPCA02179-1MG 1mg
EUR 2469

Zebrafish Gonadotropin Releasing Hormone (GnRH) Protein

20-abx653622
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  • 100 ug
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  • 1 mg
  • 200 ug
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Zebrafish Angiopoietin-1 Receptor / TIE2 (TEK) Protein

abx655203-10g 10 µg
EUR 2112.5

Zebrafish Angiopoietin-1 Receptor / TIE2 (TEK) Protein

abx655203-50g 50 µg
EUR 5300

OPCA02179-100UG - D2HGDH Recombinant Protein (Zebrafish)

OPCA02179-100UG 100ug
EUR 729

Zebrafish Metalloproteinase Inhibitor 2 (TIMP2) Protein

abx655248-10g 10 µg
EUR 2112.5

Zebrafish Metalloproteinase Inhibitor 2 (TIMP2) Protein

abx655248-50g 50 µg
EUR 5300

Zebrafish Metalloproteinase Inhibitor 3 (TIMP3) Protein

abx655257-10g 10 µg
EUR 2112.5

Zebrafish Metalloproteinase Inhibitor 3 (TIMP3) Protein

abx655257-50g 50 µg
EUR 5300

Zebrafish Stromal Cell Derived Factor 1 (SDF1) Protein

20-abx655150
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  • 100 ug
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  • 1 mg
  • 200 ug
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Zebrafish TEK Tyrosine Kinase, Endothelial (Tie2) Protein

20-abx655203
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Zebrafish HSP-70/HSPA9(HeatShock Protein 70) ELISA Kit

ELK9341-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Zebrafish HSP-70/HSPA9. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Zebrafish HSP-70/HSPA9. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Zebrafish HSP-70/HSPA9, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Zebrafish HSP-70/HSPA9 in the samples is then determined by comparing the OD of the samples to the standard curve.

Zebrafish HSP-70/HSPA9(HeatShock Protein 70) ELISA Kit

ELK9341-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Zebrafish HSP-70/HSPA9. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Zebrafish HSP-70/HSPA9. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Zebrafish HSP-70/HSPA9, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Zebrafish HSP-70/HSPA9 in the samples is then determined by comparing the OD of the samples to the standard curve.

Zebrafish Total RNA

ZFR-270 0.025mg
EUR 319

Zebrafish Transforming Growth Factor Beta 1 (TGFb1) Protein

20-abx655292
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Zebrafish Transforming Growth Factor Beta 1 (TGFb1) Protein

abx655292-10g 10 µg
EUR 2112.5

Zebrafish Transforming Growth Factor Beta 1 (TGFb1) Protein

abx655292-50g 50 µg
EUR 5300

Zebrafish Genomic DNA

GZ-270 0.025mg
EUR 177

ak2 Antibody (Zebrafish)

F54506-0.05ML 0.05 ml
EUR 140.25
Description: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.

ak2 Antibody (Zebrafish)

F54506-0.2ML 0.2 ml
EUR 322.15
Description: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.

Ada Antibody (Zebrafish)

F52652-0.08ML 0.08 ml
EUR 140.25
Description: Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity).

Zebrafish Ada Antibody

F52652-0.4ML 0.4 ml
EUR 322.15
Description: Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity).

Zebrafish Cluster Of Differentiation 40 Ligand (CD40L) Protein

20-abx652963
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  • 100 ug
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  • 1 mg
  • 200 ug
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Zebrafish Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Protein

20-abx653853
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Zebrafish Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Protein

20-abx653861
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Zebrafish Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Protein

abx653853-1ml 1 ml
EUR 2112.5

Zebrafish Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Protein

abx653861-10mg 10 mg
EUR 5300

Zebrafish Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Protein

abx653861-2mg 2 mg
EUR 2112.5

Zebrafish Atf4 Antibody

F52258-0.08ML 0.08 ml
EUR 140.25
Description: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters (By similarity).

Zebrafish Atf4 Antibody

F52258-0.4ML 0.4 ml
EUR 322.15
Description: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters (By similarity).

Zebrafish Gfap Antibody

F52537-0.4ML 0.4 ml
EUR 322.15
Description: Glial fibrillary acidic protein

Zebrafish LC3B Antibody

F53289-0.08ML 0.08 ml
EUR 140.25
Description: N/A

Zebrafish LC3B Antibody

F53289-0.4ML 0.4 ml
EUR 322.15
Description: N/A

Atg5 Antibody (Zebrafish)

F53381-0.08ML 0.08 ml
EUR 140.25
Description: Involved in autophagic vesicle formation.

Atg5 Antibody (Zebrafish)

F53381-0.4ML 0.4 ml
EUR 322.15
Description: Involved in autophagic vesicle formation.

Zebrafish LC3A Antibody

F53024-0.08ML 0.08 ml
EUR 140.25
Description: Microtubule-associated protein 1 light chain 3 alpha

Zebrafish LC3A Antibody

F53024-0.4ML 0.4 ml
EUR 322.15
Description: Microtubule-associated protein 1 light chain 3 alpha

Atg5 Antibody (Zebrafish)

F53143-0.08ML 0.08 ml
EUR 140.25
Description: Atg5 is involved in autophagic vesicle formation.

Zebrafish Thrb Antibody

R33481-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Thyroid hormone receptor beta

Zebrafish Transforming Growth Factor Beta Induced Protein (TGFbI) Protein

20-abx655306
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Zebrafish Transforming Growth Factor Beta Induced Protein (TGFbI) Protein

abx655306-10g 10 µg
EUR 2112.5

Zebrafish Transforming Growth Factor Beta Induced Protein (TGFbI) Protein

abx655306-50g 50 µg
EUR 5300

Zebrafish Tyrosine-Protein Kinase Receptor Tie-1 (TIE1) Protein

abx655412-10g 10 µg
EUR 2112.5

Zebrafish Tyrosine-Protein Kinase Receptor Tie-1 (TIE1) Protein

abx655412-50g 50 µg
EUR 5300

Zebrafish Pax2a Antibody

F52269-0.08ML 0.08 ml
EUR 140.25
Description: Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.

Zebrafish Pax2a Antibody

F52269-0.4ML 0.4 ml
EUR 322.15
Description: Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.

S1pr1 Antibody (Zebrafish)

F52393-0.08ML 0.08 ml
EUR 140.25
Description: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.

Gapdh Antibody (Zebrafish)

F52573-0.08ML 0.08 ml
EUR 140.25
Description: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins (By similarity).

Zebrafish Gapdh Antibody

F52573-0.4ML 0.4 ml
EUR 322.15
Description: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins (By similarity).

Zebrafish Stromal Cell-Derived Factor 1 / SDF1 (CXCL12) Protein

abx655150-10g 10 µg
EUR 400

Zebrafish Stromal Cell-Derived Factor 1 / SDF1 (CXCL12) Protein

abx655150-50g 50 µg
EUR 587.5

Pou3f3a Antibody (Zebrafish)

F52241-0.08ML 0.08 ml
EUR 140.25
Description: Transcription factor that may play important roles in patterning the embryonic brain.

Pou3f3a Antibody (Zebrafish)

F52241-0.4ML 0.4 ml
EUR 322.15
Description: Transcription factor that may play important roles in patterning the embryonic brain.

Zebrafish Patched Antibody

R35480-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Zebrafish patched 1, ptc1; ptc1

Zebrafish Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Protein

20-abx655248
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Zebrafish Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Protein

20-abx655257
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Recombinant Zebrafish Metallothionein-2 Protein, His, Yeast-10ug

QP9826-ye-10ug 10ug
EUR 434.4

Recombinant Zebrafish Metallothionein-2 Protein, His, Yeast-1mg

QP9826-ye-1mg 1mg
EUR 3296.4

Recombinant Zebrafish Metallothionein-2 Protein, His, Yeast-50ug

QP9826-ye-50ug 50ug
EUR 576

Gabarapa Antibody (Zebrafish)

F53276-0.08ML 0.08 ml
EUR 140.25
Description: GABA(A) receptor associated protein

Zebrafish Map1lc3a Antibody

F53023-0.08ML 0.08 ml
EUR 140.25
Description: Microtubule-associated protein 1 light chain 3 alpha

Zebrafish Map1lc3a Antibody

F53023-0.4ML 0.4 ml
EUR 322.15
Description: Microtubule-associated protein 1 light chain 3 alpha

EPDR1 (untagged)-Human ependymin related protein 1 (zebrafish) (EPDR1)

SC122862 10 µg Ask for price
EE2-responsive networks in different tissues aren’t as comprehensively outlined which is a information hole as regulated networks are anticipated to be tissue-specific. On the horizon, omics research for estrogen-mediated results in fish embody: (1) Establishing conceptual frameworks for incorporating estrogen-responsive networks into environmental monitoring packages; (2) Leveraging in vitro and computational toxicology approaches to determine chemical compounds related to estrogen receptor-mediated results in fish (e.g., male vitellogenin manufacturing); (3) Discovering new tissue-specific estrogen receptor signaling pathways in fish; and (4) Creating quantitative adversarial final result pathway predictive fashions for estrogen signaling.
As we glance forward, analysis into EE2 over the previous a number of a long time can function a template for the array of hormones and endocrine lively substances but to be absolutely characterised or found.

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